A statement was drafted by the members of the Pompidou Group’s Support Network of Professionals (SNP) working in the drug field with migrants, refugees and IDPs. The 9 professionals coming from Algeria, Croatia, Cyprus, Greece, Hungary, Italy, Portugal, Slovak Republic and Spain have analysed the impact of the COVID-19 pandemic on the lives of these social groups. They have observed that throughout 2020 these vulnerable groups have suffered disproportionately in comparison with the general population under the present circumstances. The SNP highlights the need for adequate responses protecting the physical and mental health of these most vulnerable groups. The SNP will continue working on this topic and their recommendations will be included at the Handbook for professional working with refugees, migrants and IDPs who use drugs. The Handbook will be ready by the end of 2021.